Teesside technology business could play key role in deploying a COVID-19 vaccine solution

A Teesside businessman has revealed that his company could provide the solution to the economic and rapid deployment of the vaccine for COVID-19 that the world is desperate for.

Dai Hayward said that vaccine developers from around the globe are interested in both the precision and large-scale production capability provided by Micropore’s world-leading membrane emulsification technology.

Dai Hayward MBE, chief executive of Micropore Technologies

Dai Hayward MBE, chief executive of Micropore Technologies

The technology provides a new, accurate and scalable method of creating emulsions – the process of blending insoluble liquids – which is a vital stage in the development of liposomes for a synthetic vaccine.

“It’s similar to the result you get from a kitchen blender: blitzing oil and vinegar to make dressing for your salad, although, obviously, with a great deal more control.” said chief executive Mr Hayward, whose company is based at the Wilton Centre in Redcar.

Micropore Technologies has won prestigious awards for its innovation and last year Mr Hayward was honoured with an MBE in the Queen’s Birthday Honours for his services to international trade and the North East chemical industry. But, because of the coronavirus epidemic, his medal ceremony has still to take place.

The idea behind Micropore’s membrane emulsification – injecting identical droplets through a precision engineered, laser drilled stainless steel membrane – is not new.

“But for years this has languished in laboratories because nobody could crack the engineering issues around it,” said Mr Hayward. In 2017, however, Micropore made the key breakthrough to solve the problem which had been preventing large scale production.

Micropore Technologies' AXF-7, capable of manufacturing up to 15,000 tonnes of product

Micropore Technologies’ AXF-7, capable of manufacturing up to 15,000 tonnes of product

Homogenisation – which uses equipment similar to a domestic blender – has for decades been the tried and trusted way method of emulsification, but said Mr Hayward, it can be wasteful and produce uneven sizes of particles which affect the quality and performance of the product.

There are more than 160 teams across the world trying to develop a vaccine against COVID-19. Many – including scientists at Imperial College in London – are using a process called microfluidics, which provides far more precision than homogenisation but is likely to be impractical in producing the required quantities.

“At some stage microfluidics are going to run out of road and that’s the point where we come in,” said Mr Hayward. “We have had a number of people who have come to us based on what they have done with their microfluidics approach and say they’re trying to scale up but  can’t.”

As well as pharmaceutical companies, Micropore has clients throughout the world operating in a diverse range of sectors: cosmetics, paint, oilfield chemicals, agriculture chemicals and a producer of rocket fuel.

“Our process gives you precision and therefore control over the way that the product works. The scalability then allows that to go to whatever anybody wants – and in the case of a vaccine that isn’t actually that huge in terms of quantity – but for a household laundry product that’s tens of thousands of tonnes,” said Mr Hayward.

Micropore Technologies was launched in 2003 as a spin-out business from Loughborough University.

It moved to the Wilton Centre in 2016 to benefit from its high quality laboratories and infrastructure.  It has developed a trusted network of suppliers in the Tees Valley and North East and has benefited from the support of UK Steel Enterprise and Mercia, the Northern Powerhouse investment fund.

In four years it has grown from a company employing one member of staff to a 12-strong business with employees based at the Wilton Centre and in the United States and India.  It exports 85% of its products across most of the European Union as well as South East Asia, the Far East and the Americas.

The Wilton Centre’s accommodation manager Claire Morton said it had been extremely rewarding to see at first hand Micropore’s success. “Like many of the companies based here, it has developed a unique and world-class product.  We would like to think the facilities we provide and the culture we have built have created an environment which helps scientific innovation to flourish.”

Micropore Technologies is one of a number of companies at the Wilton Centre – the region’s premier science park – which are engaged in COVID-19 work.

Another – Absolute Antibody – works with 14 of the world’s top 15 pharmaceutical companies who are trying to develop a vaccine or treatment for the virus. In the Spring it recruited six Teesside science students to support its team of 30 staff.




The Gazette 22 July 2020

The Gazette 22 July 2020